Chronic autoimmune disease with joint damage and systemic manifestations
The mechanism in three steps, and where you can intervene.
Autoimmune failure
Genetic predisposition + triggers (infections, smoking, stress) trigger an abnormal immune response
Inflammation of the synovium
Immune cells attack joints, causing proliferation of synoviocytes and production of pro-inflammatory cytokines
Joint pain and deformity
Chronic inflammation leads to erosion of cartilage and bone, morning stiffness for more than 30 minutes
Answer 3 questions to see likely causes and a baseline lab list.
How long has this been going on?
Is there marked fatigue?
Is stress high?
Likely causes
What to check
We will show a preliminary result before registration
Create an action plan in one click with a checklist, reminders, and a timeline.
If you suspect rheumatoid arthritis, it is important to get tested for inflammatory markers and autoantibodies, monitor the dynamics of symptoms and consult with a rheumatologist. You can download analyzes into Axioris and monitor indicators over time.
A baseline panel for the most common causes.
Autoantibodies present in 70-80% of patients (but not specific to RA)
More specific marker (up to 95%) for early diagnosis and prognosis
Reflects the activity of the inflammatory process
Nonspecific marker of inflammation
Detection of anemia of chronic inflammation and other systemic manifestations
How each marker relates to rheumatoid arthritis.
The exact cause of rheumatoid arthritis is unknown, but a combination of genetic predisposition (HLA-DR4 genes) and environmental triggers plays a key role. The main provoking factors: smoking (increases the risk by 2-4 times), chronic infections (periodontitis, Epstein-Barr virus), hormonal changes in women. The disease most often develops at the age of 30-50 years, with a predominance among women (3:1).
Diagnosis requires an integrated approach. In addition to laboratory tests (RF, ACCP, CRP), radiography or MRI of joints is performed to identify erosions. You can upload analysis results in PDF format to Axioris - the system will automatically recognize the values and build dynamics graphs. It is especially important to monitor CRP and ACCP: their levels correlate with disease activity and the effectiveness of therapy.
Consultation with a specialist is necessary for: morning stiffness >30 minutes, symmetrical swelling of small joints of the hands/feet, increased inflammatory markers (CRP >5 mg/l). Early diagnosis (in the first 3-6 months) helps prevent irreversible joint damage. In the application, you can set up reminders for doctor visits and follow-up tests.
1) Ignoring early symptoms (fatigue, mild joint pain). 2) Self-medication of NSAIDs without basic therapy. 3) Stop treatment if there is improvement. 4) Underestimation of extra-articular manifestations (damage to the lungs, eyes, blood vessels). Using Axioris, you can record all symptoms and tests in one place, which helps the doctor objectively assess the dynamics.
«Сын занимается спортом профессионально. Наконец выстроили нормальный контроль базовых показателей, не гадаем.»
«Загрузил 12 PDF с анализами из разных лабораторий. Всё собралось в единый таймлайн — это было неожиданно круто.»
«ТТГ оказался на границе. Без системной диагностики я бы ещё год занималась косметикой вместо причины.»
Основано на структурированном медицинском подходе, не на хаотичных советах из интернета.
Не заменяет очную консультацию и постановку диагноза врачом.
Срочные симптомы требуют немедленного обращения за медицинской помощью.
A complete cure is not yet possible, but modern drugs (biological agents, JAK inhibitors) can achieve remission in 30-50% of patients. The key factor is early initiation of therapy before irreversible changes develop.
RA is characterized by inflammatory pain (worsens at rest, morning stiffness), symmetrical damage to small joints and systemic manifestations. With osteoarthritis, the pain is mechanical (increases with load), the knee/hip joints are most often affected.
The norm is <5 mg/l. For RA: 5-20 mg/l - moderate activity, >20 mg/l - high. However, in 15% of patients, CRP may be normal even with an active process, so it is assessed in conjunction with the clinic and other markers.
If the condition is stable, monitor RF, ACCP, CRP every 6-12 months. In Axioris, you can set up reminders for scheduled examinations and track the dynamics of indicators on graphs.
A Mediterranean diet (fish, olive oil, vegetables) may reduce inflammation. It is recommended to limit red meat and alcohol. The app includes a nutrition tracker that helps identify individual flare-up triggers.
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