Short answer
Control your weight, reduce your intake of sugar and saturated fat, and check your liver enzymes (ALT, AST) and glucose levels regularly. For grade 2-3 steatosis, consultation with a gastroenterologist is required.
A metabolic disorder in which excess fat deposits accumulate in the liver, unrelated to alcohol consumption
The mechanism in three steps, and where you can intervene.
Trigger
Insulin resistance and metabolic syndrome (obesity, type 2 diabetes, dyslipidemia)
Mechanism
Impaired β-oxidation of fatty acids → accumulation of triglycerides in hepatocytes → inflammation and fibrosis
Symptom
Increased ALT/AST, ultrasound signs of steatosis, possible heaviness in the right hypochondrium
Answer 3 questions to see likely causes and a baseline lab list.
How long has this been going on?
Is there marked fatigue?
Is stress high?
Likely causes
What to check
We will show a preliminary result before registration
Create an action plan in one click with a checklist, reminders, and a timeline.
Control your weight, reduce your intake of sugar and saturated fat, and check your liver enzymes (ALT, AST) and glucose levels regularly. For grade 2-3 steatosis, consultation with a gastroenterologist is required.
A baseline panel for the most common causes.
Assessing the degree of liver cell damage
Marker of cholestasis and alcohol impairment
Detection of insulin resistance and diabetes
Assessment of dyslipidemia (especially triglycerides)
Non-invasive assessment of liver fibrosis
How each marker relates to non-alcoholic fatty liver disease (nafld).
A major factor is insulin resistance, often associated with abdominal obesity. Other reasons: high-fructose diet (juices, sweets), physical inactivity, genetic predisposition (PNPLA3 gene). NAFLD is diagnosed in 70% of patients with type 2 diabetes.
ALT usually rises before AST (ratio <1). GGTP increases when cholestasis occurs. Ultrasound shows a “bright” liver with increased echogenicity. If fibrosis is suspected, elastometry (FibroScan) or biopsy is performed.
If ALT is above 40 U/L during repeated tests, there are ultrasound signs of steatosis or metabolic syndrome. Urgently - in case of jaundice, ascites or a sharp increase in bilirubin.
1) Ignoring a slight increase in ALT (30-50 U/l) 2) Sudden weight loss (>1.5 kg/week), which provokes inflammation 3) Taking hepatotoxic dietary supplements (green tea extracts in high doses).
«Сдала ферритин по плану из диагностики — оказалось 8 при норме 30+. Через 4 месяца коррекции выпадение остановилось.»
«После второго ребёнка чувствовала себя разбитой. Анализы показали железо и ферритин в норме, но вот D₃ — 8. Решили.»
«Загрузил 12 PDF с анализами из разных лабораторий. Всё собралось в единый таймлайн — это было неожиданно круто.»
Основано на структурированном медицинском подходе, не на хаотичных советах из интернета.
Не заменяет очную консультацию и постановку диагноза врачом.
Срочные симптомы требуют немедленного обращения за медицинской помощью.
At the stage of steatosis without fibrosis - yes, with a decrease in weight by 7-10% of the original. With fibrosis of 3-4 degrees, the changes are partially irreversible.
Fructose (honey, syrups, sweet fruits in excess), trans fats (fast food), alcohol (even minimal doses aggravate the damage).
With a confirmed diagnosis - once a year. If there is fibrosis or active inflammation (ALT >80) - every 6 months.
Yes, 2-3 cups of natural coffee a day reduces the risk of fibrosis due to antioxidants, but without added sugar and cream.
Only pioglitazone and vitamin E (for biopsy-proven steatohepatitis). Statins do not harm the liver, but improve the lipid profile.
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